Embryonic Genetic Testing is usually performed through a process called Pre-implantation Genetic Disorder (PGD). Australian Concept Karachi provides recent innovative methods to treat infertility like PGD.It is a specialized technique used for diagnostic testing option for couples who are on the risk of any genetic or chromosomal abnormality.The whole process is carried out before implantation of embryo in the uterus increasing the chances of pregnancy and hence, the birth of a healthy baby.
How PGD works:
Patients are required to undergo the normal process of IVF.When the eggs reach blastocyst (5-7 days after fertilization)stage,they are accessed for PGD.It undergoes the following process:
Biopsy:
A small amount of cell (typically 5 to 7)is removed creating a small hole through microscope of a fine laser from embryo.The embryo is cryo-preserved till the results of test came.
Genetic Analysis:
The cells taken are sent to a laboratory for testing where they are screened for specific genetic disorders (e.g., cystic fibrosis, sickle cell anemia) or chromosomal abnormalities (e.g., Down syndrome, Turner syndrome).
Embryo Selection:
Based on the results,the normal embryo free of any abnormality is selected for frozen-embryo transfer using natural menstural cycle.However,if any embryo or cell is found detected abnormal implantation doesnot proceed further.
When should you do PGD?
Australian Concept Karachi advises patients to undergo PGD treatment when:
*A female of greater age above 35 and had any previous medical history of miscarriages.
*If there is history of sickle cell anemia or cystic fibrosis or any other abnormality among family of the couple.
*When Parents chromosomes are stucturally compromised.
Applications of PGD:
Australian Concept Karachi use the process of PGD among patients who has:
*Carrier Screening *Chromosomal Screening
*Inherited Diseases *Sex Selection
*Recurrent Pregnancy Loss
Advantages of PDG:
PDG is performed during IVF-ICSI process for couples who have high chances of any disease or abnormality transfering to their un-born child.
1.PDG is advisable for the conception of a healthy baby.
2.It helps avoid ethical dilemmas related to later pregnancy termination due to detected abnormalities.
3.It is an invaluable tool in modern infertility treatments giving hope to the couples eliminating the risks of disorders.
PGD Constraints:
Where PGD is an premium solution for couples dealing with infertility issues,it has certain limitations as well
Costly:
PGD adds significant expense to the IVF process through its testing.
In-Completeness:
PGD can only be tested for the conditions for which it is specifically designed to detect.
Intrusive:
Though generally safe, the embryo biopsy carries a small risk of damage through incision.
Ethical Concerns:
Some question of ethics in genetic screening and selection are raised by people.But,it is generally carried out for reproduction options.
Intracytoplasmic Sperm Injection;All you need to know:
Australian Concept Karachi provides Intra-cytoplasmic Sperm Injection(ICSI) along with In-Vitro Fertilization(IVF) to achieve fertilization where there are cases of male infertilization and previous IVF treatments have failed.Intra-cytoplasmic is basically a gel like substance in the center of an egg which is made of water,salt and other molecules.
ICSI enables impregnation by direct putting an injection of a single sperm into a single egg. Still, there are chances that ICSI doesn’t guarantee fertilization.It occurs only when the embryo gets attached to the lining of uterus.
Sperms Collection:
It might take place on the same day when the eggs are collected from a female.It is necessary to consider two points:
*The person giving the sperm must not indulge in any sort of sexual activity and masturbation 2-3 days before collection.
*The person is only allowed to masturbate at home or in a private room at a fertility clinic, giving the the ejaculation specimen to the laboratory within 60 minutes from ejaculation.
*People who experience azoospermia, anejaculation or retrograde ejaculation may need a procedure(operation) to collect sperm. It involves vasectomy reversal and procedures like electroejaculation and microscopic testicular sperm extraction
A semen analysis is carried out to check sperm motility,quality and quantity.
How does ICSI works?
In the process,reproductive endocrinologis takes out healthy sperm using a microscope.The sperm is directly injected in the cytoplasm of a mature egg using a fine needle.It is monitored to ensure that fertilization occurs then it is transferred to uterus where the developing embryo gets attached to the lining of uterus.
Who should undergo ICSI:
Australian Concept in Karachi usually recommends ICSI treatment to treat infertility among males.It is used:
*When a person is suffering ftom anejaculation,low sperm count and,poor sperm quality.
*Retro-grade ejaculation
*Blockage in male Reproductive system
*A condition where traditional IVF methods have failed
*Couple above 35 age
*Cryopreservation(frozen eggs or sperms) are used in conception.
What are benefits of ICSI?
Australian Concept Karachi help many couple to achieve their dream of having a family.
*It increases the chance of fertilization
*It allows a couple to have greater chances of fertility reducing male sterility.
What are some risks while undergoing ICSI:
There are certain limitations as well:
*ICSI doesnot guarantee 100% fertilization or pregnancy results.
*It also increases the risk of infertlity in males creating more genetic abnormalities.
* There is a myth pertaining ICSI that the health of the couple or the embryo may be compromised as the process involve will be too hectic to be carried out.But,it is not true.
Cost of ICSI:
The procedure of ICSI is slightly higher than the normal IVF treatment because it is more advanced and use specialized micromanipulation equipment and tools like microscopes and needles for accuracy.
Australian Concept Karachi Infertility Medical Center gives a lesser expensive and economical plan based on installments and customization.
Happy News for the coming baby:
ICSI is used to fertilize multiple eggs. If you decide to transfer more than one embryo, you might expect the surprise of having twins, triplets or more. A multiple pregnancy can increase the risk of premature birth and other complications for the mother and babies.
In the United States, approximately 2% of babies are born with congenital conditions (born with a certain health conditions) and 1% of children conceived with ICSI have congenital conditions so it maybe a natural way.So a child may be born with Angelmen Syndrome,Austism,Disorders of sex differentiation,Hypospadias and intellectual dis-abilities.
Success Rate of ICSI:
Australian Concept Karachi ensure about 85% of fertilization and reproduction using ICSI method.However,fertilization and pregnancy are two different things.In some cases,fertilization may occur but the pregnancy doesnot continues till the developing embryo gets attached with the lining of uterus.
