Breakthrough: First malaria vaccine developed

Team HTV Dec 07 2015
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World’s first malaria vaccine has cleared one of the very last hurdles from European drugs regulators who recommended it as safe and effective to use on babies in Africa at risk of the mosquito-borne disease.

The shot, called ‘RTS, S’ or Mosquirix, will be the first licensed human vaccine towards a parasitic ailment and could assist save you millions of cases of malaria in countries that use it. The vaccine turned into advanced through GlaxoSmithKline (GSK).

Malaria is among the largest killers of infants and children around the world, claiming the life of one toddler each minute. It infects round two hundred million people a year; the disease killed an anticipated 584,000 human beings in 2013, the widespread majority of them being children in sub-Saharan Africa.

Andrew Witty, GSK’s chief executive, said that the European Medicines Agency’s (EMA) high-quality support was a vital step in the direction of making the world’s first malaria vaccine.

“While ‘RTS, S’ on its own is not the complete answer to malaria, its used alongside those interventions … such as bed nets and insecticides which would provide a very meaningful contribution to controlling the impact of malaria on children in those African communities that need it the most,” Witty said.

Mosquirix was assessed for safety and efficacy by a special manner that allows the EMA to assess a product. Worldwide health experts have hoped for a long time that scientists would be able to broaden a powerful malaria vaccine, and researchers at GSK have been operating on RTS, S for 30 years. The shot additionally carries an adjuvant, or booster, made with the aid of US Biotech employer Agenus.

Expectations that Mosquirix could be a final solution to eliminate and eradicate malaria were dampened when trial data published  in 2011 and 2012 showed it reduced episodes of malaria in babies aged 6-12 weeks by only 27 percent, and by around 46 percent in children aged 5-17 months.

Some malaria professionals have expressed difficulty with the complexities and potential costs of deploying this primary vaccine when it presents only partial protection, making it much less appealing and more risky. “The timing, duration, and outcomes of some of the critical steps to possible vaccine implementation in African countries are not yet known,” said David Kaslow, PATH’s vice president of product development.

But Joe Cohen, a GSK scientist who has led the development of Mosquirix since 1987, said he had no question the vaccine could considerably reduce the toll of illness and death because of the malaria amongst African kids.

GSK has promised it’s going to make no profit from Mosquirix, pricing it at the value of manufacture plus a five percent margin, which it’s going to reinvest in research on malaria and other not noted tropical sickness.

About the author: Muhammad Hammad is a final year medical student at Ayub Medical College. Research is his passion.

Article source: http://blogs.jpmsonline.com/2015/09/19/malaria-vaccine-receives-a-green-signal-a-breakthrough-in-malaria-prevention/

Team HTV

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